The blockbuster weight loss drug sold as Ozempic and Wegovy [has, on 21 March, gone] generic in countries that are home to 40 percent of the world’s population, significantly lowering the price of a costly medicine that had been largely unaffordable to nearly all but the wealthiest people. On Saturday, Novo Nordisk, the company that until now has had a monopoly on selling the drug, will lose patent protection in several of the world’s most populous countries. The first generic versions are expected to arrive in India as soon as this weekend. In the coming months, the generics are also expected to become available in China, Canada, Brazil, Turkey and South Africa.

  • Allero@lemmy.today
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    5 days ago

    Here comes a gentle reminder: Ozempic is primarily meant as a medicine for type 2 diabetes and non-alcoholic fatty liver disease. It has plenty of side effects, does not lead to long-term weight loss and may harm you in the long run. It may be helpful, but it shouldn’t be taken uncontrollably.

    Consult your physician to determine if it’s the best way forward.

    • JennaR8r@lemmy.dbzer0.com
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      4 days ago

      I’ve been on it for 2 years for weight loss/maintenance and it’s life-changing & I wish this existed 30 years ago, my entire life & self-esteem would’ve made me a completely different person so much more confident & goal-achieving

  • sakuraba@lemmy.ml
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    4 days ago

    edit: man imagine being angry that a drug has gone generic so more people can benefit from it, i hope all you removed and removed

    I hope it comes soon here, I’m prediabetic and was starting to be unable to hold myself up for more than 5 minutes without a sharp pain in my back that made me unable to do a lot of things (except work of course)

    Right now I’m on fentermine and it helps my audhd but the main effect is that now I don’t feel the urge to eat huge volumes of food just to feel “good” and bloated for the next 4 hours. I already lost 10 kilos and it let me start exercising. Good shit but I’m already on the last half of my treatment

    I hope no-one is in a position where their own body betrays them with a chemical imbalance that leads them to not make the best decisions for their health, because after reading some comments some of you would commit suicide before taking any “stupid pill”-

  • JasonDJ@lemmy.zip
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    6 days ago

    Ok so how can I get generic ozempic from India, because here in the US there probably won’t be a generic until at least 2032 due to how our patent laws work.

      • Nawor3565
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        6 days ago

        Yes, my understanding is that it’s legal in the US to purchase prescription-only drugs from overseas as long as they’re only for personal use. It’s kind of a grey area but as long as they’re not scheduled substances, I and multiple people I know have saved a lot of money by buying prescription drugs from Europe and shipping them here (we have such a wonderfully broken system here, don’t we?)

        • CmdrShepard49@sh.itjust.works
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          6 days ago

          If you go to border towns in Mexico like Tijuana they have pharmacies on every corner like Starbucks where you can buy medications.

          • Vupware@lemmy.zip
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            5 days ago

            Genuinely: are we still crossing borders? I’ve stopped even considering it given… everything.

    • cogitase@lemmy.dbzer0.com
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      6 days ago

      I’ve purchased generic medications on DNMs before. There was a user “Indiapilldaddy” who sold hundreds of different generics. Antibiotics, antivirals, cholesterol, blood pressure, etc. With the review system on the DNMs it’s probably more trustworthy than some random website that pops up.

  • teolan@lemmy.world
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    5 days ago

    We’re not able to regulate the food and automobile industry so we’re going to drug everyone forever so that we don’t end up like the Pixar spaceships. In 20 years we’ll discover the side effects and everyone will be shocked.

  • sga@piefed.socialM
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    6 days ago

    From the reports that i have read (am indian), 20+ generics are expected, within roughly 2 months or so, with previous price being something along 10k INR (roughly 100USD) a month to about 3-4k INR (30-40 USD) a month. Drugs have always been kinda cheap here (as an example, a simple paracetamol (tylenol) tablet costs 1 INR (~1cent US)), so it is still expensive (for vast majority, it is more than 2-3 days of work), but much better. hope people use this cautiously though with reasonable expectations.

    • MangoCats@feddit.it
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      6 days ago

      Sounds to me like the US is going to continue to be a country of morbidly obese poor people in a much skinnier world.

        • MangoCats@feddit.it
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          5 days ago

          There are morbidly obese people all over the world, but the US does fat more bigly and with more of the population than any country I know… Looking it up with Google - lots of Pacific Island countries have slightly more obese people than the US (which is at 42%), also Kuwait, Qatar, Saudi Arabia and Egypt are tipping the scales in the US overweight class, but yeah - US is a world leader in total number of fat people, by a big margin - though China is growing quickly and may soon outweigh the US in total numbers, if not percentage of the population.

            • MangoCats@feddit.it
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              4 days ago

              This is a food supply problem with a drug solution. You know what happened 35 years ago? Tobacco was banned in most US public spaces. You know where TOBACCO MONEY went? Processed foods. Sugar was replaced with HFCS - not just for the profit factor, but also because of the psycho-bio ramifications of mass consumption of HFCS. These are the same people who did meticulous scientific research on nicotine addiction, inhalation patterns, etc. and never published any of it. What do they know about food that they didn’t share, but put into practice in your grocery stores and restaurants?

  • Hanrahan@slrpnk.net
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    4 days ago

    i tried it briefly for a couple months, got embarrassed at myself for my brief moment of insanity that I had tried it and stopped.

    observing all this is beyond my ability to any longer have sympathy for the human race as a whole . Instead of banning cars, starbucks and fast food etal we design a drug to sell to you.

    Like many of the endless examples of human stupidity, it seemingly makes lots of sense at an individual level and is completely fucking insane at a societal level.

    • YeahIgotskills2@lemmy.world
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      4 days ago

      If you look at photos and footage from like 50 years ago, everyone was way thinner. I don’t believe we’ve just got greedier. I don’t believe people were necessarily choosing healthier options. The food has changed and is practically poisonous. People don’t want to be this way and I don’t think it’s fair to blame them directly.

  • andybytes@programming.devBanned
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    6 days ago

    yet we could just improve our culture and our food supply but I guess a pill will do. Good luck with them hershey squirts you filthy animals.

    • CyberEgg@discuss.tchncs.de
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      6 days ago

      Oh, great, thanks for that advice. My mental and physical preconditions just stopped influencing my eating and workout habits and fixed my metabolism, nice!

    • themurphy@lemmy.ml
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      6 days ago

      While I agree that in best case, everyone could control themselves. But I think you misunderstand what the drug does.

      It makes you not wanting to eat as much. The pill doesnt make fat magically go away.

      Which effectivly would fix the food supply issue.

      But I do agree that there’s a cultural problem, especially in the US.

    • kazerniel@lemmy.world
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      6 days ago

      “just improve our culture and our food supply”

      …as if it was that easy 😅 Especially with the interwoven net of geographical factors, industrial lobbying and tradition/consumer taste.

    • Yttra@lemmy.world
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      6 days ago

      Pretty cool for folks with type 2 diabetes, but that’s if they can still get any sort of supply.

    • 🍉 Albert 🍉@lemmy.world
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      6 days ago

      isn’t it meant to be a permanent treatment?

      no one says insulin is inefficient because diabetics die if they stop taking it.

      • paraphrand@lemmy.world
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        6 days ago

        Exactly. And these drugs were originally diabetes medications. And they don’t cure diabetes.

        • SaveTheTuaHawk@lemmy.ca
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          4 days ago

          the only reason they were diabetes meds was because obesity and high carb intake is the cause of most type 2 diabetes.

          All these drugs do is trick the brain into thinking you just over ate.

      • quickenparalysespunk@lemmy.dbzer0.com
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        5 days ago

        sorry but some people do say it’s inefficient and unfair. insulin is not free (not in all countries at least) and it’s extra effort and task management which is forced on people, some of them just because they were born with diabetes and never had a choice.

        it’s like a tax for being born a certain way.

        • 🍉 Albert 🍉@lemmy.world
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          5 days ago

          insulin is practically free to make, is about a couple $ per month without subsidies.

          If you pay more than that it is a literal scam and people belong in jail.

          • SaveTheTuaHawk@lemmy.ca
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            4 days ago

            insulin is practically free to make, is about a couple $ per month without subsidies.

            No drug is inexpensive to make at GMP level.

    • TBi@lemmy.world
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      6 days ago

      I think you need to make permanent changes to lifestyle and eating to keep weight off. If you return to your old ways then the weight comes straight back on. Just like a crash diet.

    • MangoCats@feddit.it
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      6 days ago

      the weight lost from these drugs were all regained within two years after stopping the drug.

      So you have to buy and take the drug FOREVER!!! Why do you think they went to the trouble to develop and release it?

      • otp@sh.itjust.works
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        6 days ago

        I believe they work by lowering your appetite, generally leading to less eating, especially snacking.

        Even liposuction, literally taking the fat out of the body, doesn’t result in permanent weight loss.

        What do you expect a drug to do to make you skinny without it needing to become something you take regularly? If you want to lose weight permanently, you have to work for it, no matter which strategy you use.

        • MangoCats@feddit.it
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          6 days ago

          If you want to lose weight permanently, you have to work for it, no matter which strategy you use.

          What people want is the magic pill that they take once and they look like Cindy Crawford at 26 years old forever.

          without it needing to become something you take regularly?

          There are the structural things - removing parts of the intestine, installing restrictive bands around the stomach. One they haven’t talked about much that would probably work if we had the knowledge and bravery to try it would be physical modification of the brain, either by ablation or slightly less risky with neurostimulation (deep brain stimulation)…

          https://karger.com/sfn/article-abstract/100/2/75/826710/Effectiveness-of-Deep-Brain-Stimulation-in

          • sakuraba@lemmy.ml
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            4 days ago

            There are the structural things - removing parts of the intestine, installing restrictive bands around the stomach.

            Both of them require a surgery and can have HUGE complications. Oh yeah and they are not a permanent solution, just as ozempic they just help to start developing better habits, you will regain weight after sometime if you don’t keep a better diet even with these procedures

            • MangoCats@feddit.it
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              4 days ago

              can have HUGE complications.

              Agreed. What most people don’t realize is that meds can, and do, have HUGE complications too.

              you will regain weight after sometime if you don’t keep a better diet even with these procedures

              Agreed. The structural solutions, including brain stim, give a significant period of opportunity for learning better habits - for people who actually want to lose the weight and keep it off it can get them “over the hump” into a pattern that doesn’t relapse. Just like opiate addiction, there are things that take significant time for your body/mind to get out of the habit with food, and any addictive behavior really.

              Of course if you’re determined to live a life of gluttony, these things are all temporary - even more temporary than life itself.

              • sakuraba@lemmy.ml
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                4 days ago

                Of course if you’re determined to live a life of gluttony, these things are all temporary - even more temporary than life itself.

                You could just not assume that? It’s not about determination, as you said, it is an addiction. The root cause is not a food addiction, we literally need food to survive, but that root cause is different for every person and unless you are that same person you just don’t assume shit about intentions or determination.

                • MangoCats@feddit.it
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                  4 days ago

                  There’s a large grey area between determination and uncontrollable addiction.

                  that root cause is different for every person and unless you are that same person you just don’t assume shit about intentions or determination.

                  Very true. Some “diet aides” work well, some help a little, most barely work at all. Then there’s the influence of environment - how likely a gambling addict is to relapse can be strongly influenced by whether they live in Las Vegas or Salt Lake City. Heroin addicts in Seattle have a much harder time kicking the habit there than in Atlanta.

                  As for food, do you eat socially? In restaurants? My wife and I have started taking the “Senior Citizens’ discount” on restaurant food by simply ordering one entree and sharing it instead of overstuffing ourselves on separate dishes.

                  All these factors come into play, and still some people in the US are avoiding obesity, but not many - and IMO that’s down to the food / social / economic environment we live in here - it’s not healthy, but it is good for the medical business.