I unfortunately live in a not very trans friendly state in the US (more like trans hostile tbh) so I’ve been doing my HRT pretty much solo/without seeing doctors. Been doing mono estradiol enanthate for about a year now following the manufacturer’s recommendations (0.15 mL every 7 days) and wanted to try getting on prog but i’m not sure what dosage i should be at. any recommendations?
100 mg, rectally, once per night - taking it orally results in the dose almost entirely being absorbed by the liver and does not sufficiently raise blood progesterone levels, so rectal administration ensures you actually are getting the dose. Unfortunately it’s the only realistic alternative route of administration to oral, currently.
Also, you want to take micronized bioidentical progesterone (the ones that are in oil and come in gel capsules intended to be taken orally, they are safe to insert rectally). You don’t want to take medroxyprogesterone acetate (MPA) which is often called “progesterone” and which some trans women have taken (esp. historically). MPA has some negative long-term health risks associated with it..